Considering that cooling in cooling systems is more costly than heating, the importance of refrigerant selection in cooling systems is even more obvious. Due to the complexity of the refrigerant selection problem, a multi-criteria decision approach must be used to implement a thorough and organized evaluation of the factors. The purpose of this study is to evaluate the criteria to be considered when choosing refrigerants using the interval type-2 trapezoidal fuzzy Analytic Hierarchy Process (AHP). As a result, the most important and least crucial refrigerant selection criteria are determined by calculating the weights and obtaining the ranking of the requirements. In this way, the refrigerant selection criteria are prioritized, and the most crucial factor in refrigerant selection has emerged as energy efficiency. In light of the results, it has become clear that it is now essential for everyone in the world to use environmentally friendly, highly effective refrigerants.